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Issue Date: March 2010


Best Doctors 2010: A new way to predict effectiveness of chemotherapy

Dr. Afshin Dowlati
Ryan Dezember

Doctors often have trouble knowing who might respond to certain cancer treatments. “We kind of give chemotherapy and wish for a good result,” says Dr. Afshin Dowlati of University Hospitals Ireland Cancer Center. That could change. Dowlati led a study that revealed lung cancer patients with low levels of a molecule that controls cellular interaction have twice the chance of responding to chemotherapy than those with high levels. Those levels can also predict how likely a patient is to live a year after diagnosis. The difference could help patients decide whether to try chemotherapy, drugs or pursue alternative therapies, Dowlati says.


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